Identify the minimal set of biochemical reactions to add to a draft metabolic model to enable production and consumption of as many exometabolites as possible
This algorithm adds a drain flux for each exometabolite and forces these drains to operate in the approapriate direction.
Team members who developed & deployed algorithm in KBase: Chris Henry, Janaka Edirisinghe, Jose Faria, Trent Northen, Ben Bowen. For questions, e-mail help@kbase.us
Related Publications
- [1] Henry CS, DeJongh M, Best AA, Frybarger PM, Linsay B, Stevens RL. High-throughput generation, optimization and analysis of genome-scale metabolic models. Nat Biotechnol. 2010;28: 977 982. doi:10.1038/nbt.1672 , https://www.nature.com/articles/nbt.1672
App Specification:
https://github.com/cshenry/fba_tools/tree/b083384ac00d4f9d7cb796a664ee3ffd017cf248/ui/narrative/methods/fit_exometabolite_dataModule Commit: b083384ac00d4f9d7cb796a664ee3ffd017cf248