The Department of Energy Systems Biology Knowledgebase (KBase) is a software and data platform designed to meet the grand challenge of systems biology: predicting and designing biological function. KBase integrates data, tools, and their associated interfaces into one unified, scalable environment, so users do not need to access them from numerous sources or learn multiple systems in order to perform sophisticated systems biology analyses.
A collaborative computational environment is needed to bring researchers together to share and integrate large, heterogeneous datasets in order to develop predictive models and drive scientific discovery. A common framework for managing and sharing the systems biology datasets, workflows, software, models, best practices, and other relevant knowledge will increase the scientific return on investment and empower researchers to reproduce published results and review projects more effectively–cornerstones of the growing Open Science movement. Achieving a systems-level understanding of biology will allow researchers to predict and ultimately design how biological systems will function under particular conditions. (See What is KBase for more information.)
If you signed up for KBase and yet your password does not seem to work, you may reset your password at any time. All you will need is access to the email account you originally signed up with. The password reset function is available from this various mentions on this site (e.g. search for “reset”), or from the Narrative Interface login form.
None! You don’t need anything other than a web browser, which you already have (you’re reading this FAQ on it). KBase works on most modern web browsers, including Firefox, Chrome, and Safari. See the Supported Browsers page for more information.
For additional help and guidance on reporting issues, see our troubleshooting tips.
KBase is not just a database–it includes tools and user interfaces as well as data. We have integrated data from a wide range of public resources. It is also possible for users to upload their own data and decide who to share it with.
We do not directly curate data; we take annotations from public resources and users’ uploaded data. KBase does, however, provide tools and services to assist in user annotation and curation.
We believe that you will ultimately help both yourself and other researchers by sharing your Narratives so that others can see what you were thinking, what you did, and what you concluded from your analyses. However, rest assured that all of your data and Narratives are private (viewable only by you) until you decide to share them. You can choose to share a Narrative with specific collaborators or with everyone.
The KBase team presents at various conferences and conducts workshops for end users and developers. Check our calendar of events to find out when and where these will be. In the near future, KBase will be offering various types of training and collaboration with users and developers: tutorials based on current KBase tools and interfaces, bootcamps focused on educating community developers on how to develop computational tools in KBase, and webinars and workshops targeting particular scientific problems.
If you would like to host a KBase workshop at your organization, please contact us.
Yes, we do. If you’ve never used KBase before, start with the “New to KBase?” page. The Narrative Interface guide and the Data Upload/Download guide will teach you about those key KBase interfaces. The Narrative Tutorials such as Assemble and Annotate, show step-by-step analysis examples. Not only can you read through an example of how to assemble and annotate data in KBase; you can make your own copy of the Narrative tutorial and run the steps yourself, even changing the parameters or uploading your own datasets to analyze.
For more documentation links please refer to the Docs menu.
A printable four-page KBase brochure is available as a PDF.
Nearly all KBase software is publicly available through GitHub, where it can be reviewed and extended by the community.
KBase’s open source software license can be viewed here.
Yes! The KBase SDK offers members of the KBase community a mechanism to add open-source, open-license (e.g., GNU Public License) tools to KBase, so that they run on KBase’s computational architecture and are available through the KBase Narrative Interface. See the Developer Information page for more information.
Arkin AP, Cottingham RW, Henry CS, Harris NL, Stevens RL, Maslov S, et al. KBase: The United States Department of Energy Systems Biology Knowledgebase. Nature Biotechnology. 2018;36: 566. doi: 10.1038/nbt.4163
Please see Contact Us. In our new KBase Help Board, you can engage in a two-way dialog with KBase staff without revealing your email address.