Neurospora crassa metabolic modeling and genome analysis
Here, we've imported datasets to enable analyses in KBase narratives. We've imported the published metabolic model of Neurospora crassa, which was built, manually curated, and validated by Dreyfuss et al. The genome of Neurospora crassa was retrieved from NCBI RefSeq (GCF_000182925.2) and was sequenced by the Broad Institute. Gene expression data was produced by the Joint Genome Institute and described in the publication by Wu et al.
Furthermore, genome analysis tools and datasets can be accessed at the MycoCosm portal page: https://mycocosm.jgi.doe.gov/Neucr2/Neucr2.home.html
- Dreyfuss JM, Zucker JD, Hood HM, Ocasio LR, Sachs MS, Galagan JE. Reconstruction and validation of a genome-scale metabolic model for the filamentous fungus Neurospora crassa using FARM. PLoS Comput Biol. 2013;9(7):e1003126. doi:10.1371/journal.pcbi.1003126
- Galagan JE, et al. The genome sequence of the filamentous fungus Neurospora crassa. Nature. 2003;422(6934):859-68. doi: 10.1038/nature01554.
- Wu VW, et al. The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus. PNAS. 2020;117(11):6003-6013. doi:10.1073/pnas.1915611117