The Department of Energy Systems Biology Knowledgebase (KBase) is an emerging software and data environment designed to enable researchers to collaboratively generate, test and share new hypotheses about gene and protein functions, perform large-scale analyses on a scalable computing infrastructure, and model interactions in microbes, plants, and their communities. KBase provides an open, extensible framework for secure sharing of data, tools, and scientific conclusions in predictive and systems biology.

KBase includes

  • 925 data types
  • 5695 bacterial/archaeal genomes
  • 175 eukaryotic genomes
  • 4985 models
  • 23 services
  • 821 functions

What can KBase do?

  • Efficiently annotate new microbial genomes and infer metabolic and regulatory networks.
  • Transform network inferences into metabolic models and map missing reactions to genes using novel data reconciliation tools.
  • Test microbial ecological hypotheses through taxonomic and functional analysis of quality-assessed metagenomic data
  • Discover genetic variations within plant populations and map these to complex organismal traits.